Dual & Triple Agents
A Unified Approach
A Unified Approach
WHAT ARE THEY? WHY DO THEY MATTER?
HOW CAN THEY IMPACT YOU?
Most people have heard of GLP-1 medications like semaglutide or liraglutide.
Dual and triple agonists are the newest versions of these medicines.
They work on more than one hormone at the same time, which makes them stronger:
Dual agonists (like tirzepatide) work on two hormones
Triple agonists (like retatrutide) work on three hormones
These hormones help control blood sugar, reduce hunger, and support weight loss.
Better blood sugar control
Studies show:
Regular GLP-1 meds lower A1C about 1–1.8%
Tirzepatide can lower A1C up to 2.4%
Triple agonists show similar or even stronger effects in early research
This means many people see better diabetes control even if past medications didn’t work well enough.
Stronger and more consistent weight loss
These medicines work on the brain areas that control hunger, cravings, and fullness.
People in major clinical trials lost:
15–22% of their body weight on tirzepatide
Up to 24% on retatrutide — the highest weight loss ever seen in medication studies
Many people say they:
Get full quicker
Think about food less
Have fewer cravings
Can stick to healthier habits more easily
Why Do Triple Agonists Work So Well?
The triple agonist (retatrutide) also boosts your metabolism — meaning your body burns more calories naturally.
Even though one of the hormones it activates (glucagon) normally raises blood sugar, the medication balances this perfectly, so blood sugar doesn’t spike.
The result:
Stronger fat-burning and more weight loss without loss of blood sugar control.
Who These Medicines May Help
Dual and triple agonists may be a good fit for:
People with type 2 diabetes who need stronger blood sugar control
Anyone with obesity, or a BMI of 27+ with weight-related health issues
People who plateaued or didn’t respond strongly to semaglutide or other GLP-1s
People with fatty liver, insulin resistance, or trouble losing weight despite trying
Dual and triple agonists are next-generation treatments that help with:
Better blood sugar control
Significant and reliable weight loss
Lower blood pressure
Improved cholesterol
Lower liver fat
They don’t just treat diabetes or obesity separately — they help improve your overall metabolic health.